1. Facilitating Translational Nanomedicine via Predictive Safety Assessment 
Vahid Mirshafiee, Wen Jiang, Bingbing Sun, Xiang Wang, Tian Xia 
Molecular Therapy 
Volume 25, Issue 7, Pages (July 2017)
DOI: /j.ymthe
Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

2. Molecular Therapy 2017 25, 1522-1530DOI: (10.1016/j.ymthe.2017.03.011)
Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

3. Figure 1
Major Exposure Routes of ENMs with Distinct Physicochemical Properties for Medicinal Applications
Physicochemical properties of ENMs and their route of administration determine their interaction at the nano-bio interface and cytotoxicity.
Molecular Therapy  , DOI: ( /j.ymthe )
Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

4. Figure 2
SARs Linking ENM Physicochemical Properties to Adverse Outcome Pathways
Examples of ENM-induced toxicity mechanisms include lysosomal damage by cationic nanocarriers, NLRP3 inflammasome activation for REO NPs and high aspect ratio nanomaterials, membrane perturbation by 2D nanomaterials and Si-NPs, and lipid peroxidation and ROS generation by silver and metal oxide NPs.
Molecular Therapy  , DOI: ( /j.ymthe )
Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions