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Establishment of Xenogeneic Lung Chronic Graft-Verus-Host Disease Mice Model  Hisaki Fujii, MD, PhD, Zhijuan Luo, MD, Xinghua Wang, MD, Susan Newbigging,

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Presentation on theme: "Establishment of Xenogeneic Lung Chronic Graft-Verus-Host Disease Mice Model  Hisaki Fujii, MD, PhD, Zhijuan Luo, MD, Xinghua Wang, MD, Susan Newbigging,"— Presentation transcript:

1 Establishment of Xenogeneic Lung Chronic Graft-Verus-Host Disease Mice Model 
Hisaki Fujii, MD, PhD, Zhijuan Luo, MD, Xinghua Wang, MD, Susan Newbigging, MSc, DVM, DVSc, Armand Keating, MD, R. Maarten Egeler, MD, PhD  Biology of Blood and Marrow Transplantation  Volume 20, Issue 2, Pages S266-S267 (February 2014) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Engraftment of human cells in NSG mice
Lung or liver from NSG mice 8 weeks post transplantation were examined for human CD4, CD8, CD20 and CD68 engraftment by IHC. Three randomly selected sections per slide were observed under the x40 objective. Data were calculated as: % positive cells = positive nuclei cells Ú total cells nuclei x 100. Biology of Blood and Marrow Transplantation  , S266-S267DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 Lung fibrosis in NSG mice 8 weeks after transplantation
The lung from NSG mouse bearing PBMCs (A) or CD34+ cells (B) 8 weeks after transplantation was stained with Masson's trichrome. Fibrosis is shown in blue. Biology of Blood and Marrow Transplantation  , S266-S267DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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