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The Bony Side of Endothelial Cells in Prostate Cancer

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Presentation on theme: "The Bony Side of Endothelial Cells in Prostate Cancer"— Presentation transcript:

1 The Bony Side of Endothelial Cells in Prostate Cancer
Jia Peng, Yibin Kang  Developmental Cell  Volume 41, Issue 5, Pages (June 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 PCa Induced Bone Formation via Endothelial-to-Osteoblast Conversion BMP4 (and possibly other factors) secreted from PCa cells upregulates OSX expression in Tie2+ endothelial cells, which undergo EC-to-OSB conversion to generate bone-forming osteoblasts in prostate cancer lesions. The EC-to-OSB conversion and new bone formation promote the growth of PCa tumors. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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