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Harnessing Host Defenses to HIV

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Presentation on theme: "Harnessing Host Defenses to HIV"— Presentation transcript:

1 Harnessing Host Defenses to HIV
Cell  Volume 155, Issue 3, (October 2013) DOI: /j.cell Copyright © Terms and Conditions

2 The HIV drug maraviroc (orange) locks CCR5 (blue) in an inactive conformation. Image courtesy of B. Wu. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

3 Reverse-transcribed HIV cDNA binds to and activates cGAS, which produces the second messenger cGAMP to activate STING and trigger innate immune responses. Figure courtesy of D. Gao. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

4 Some interferon-stimulated genes (ISGs) inhibit HIV DNA (blue) synthesis, and MX2 (orange) prevents its nuclear accumulation. Figure courtesy of M. Malim. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions


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