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Harnessing Host Defenses to HIV
Cell Volume 155, Issue 3, (October 2013) DOI: /j.cell Copyright © Terms and Conditions
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The HIV drug maraviroc (orange) locks CCR5 (blue) in an inactive conformation. Image courtesy of B. Wu. Cell , DOI: ( /j.cell ) Copyright © Terms and Conditions
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Reverse-transcribed HIV cDNA binds to and activates cGAS, which produces the second messenger cGAMP to activate STING and trigger innate immune responses. Figure courtesy of D. Gao. Cell , DOI: ( /j.cell ) Copyright © Terms and Conditions
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Some interferon-stimulated genes (ISGs) inhibit HIV DNA (blue) synthesis, and MX2 (orange) prevents its nuclear accumulation. Figure courtesy of M. Malim. Cell , DOI: ( /j.cell ) Copyright © Terms and Conditions
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