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Bacterial Genomics and Pathogen Evolution

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Presentation on theme: "Bacterial Genomics and Pathogen Evolution"— Presentation transcript:

1 Bacterial Genomics and Pathogen Evolution
David M. Raskin, Rekha Seshadri, Stefan U. Pukatzki, John J. Mekalanos  Cell  Volume 124, Issue 4, Pages (February 2006) DOI: /j.cell Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Proposed Evolution of Spirochete Species Deduced through Comparative Genomics Comparison of T. denticola predicted ORFs with other completed Spirochete genomes. The circle in the inset represented T. denticola ORFs that had no significant matches (E < 10–5) in the other sequenced genomes. Td, T. denticola; Tp, T. pallidum. Cell  , DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

3 Figure 2 Comparative Genomics-Based Model for the Evolution of Toxigenic V. cholerae Strains The wealth of genomic data available for different V. cholerae strains suggests that toxigenic V. cholerae originated from nonpathogenic precursors by stepwise acquisition of virulence genes through horizontal transfer (see text for details). CTX, cholera toxin; TCP, toxin coregulated pilus; O1, O139, O37, and O39, various O antigen clusters; VSP-I, seventh pandemic island; T3SS; type III secretion system; VAS genes, virulence-associated secretion genes; TLC, toxin-linked cryptic. Cell  , DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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