1. PEARLS OF WISDOM WITH COMBINATION THERAPY IN PAH

2. Program Overview

3. Evolution of PAH Treatment

4. Why Combination Therapy for PAH?

5. Case Presentation

6. Natural Course of Pulmonary Hypertension

7. Contemporary Types of Combination Therapy for PAH

8. Rescue Therapy Concept: Add-On Agents When Patient Deteriorated

9. Goal-Oriented Therapy: Bring Patient to Treatment Goals With Multiple Agents

10. Recent Trials of Sequential Combination Therapy

11. SERAPHIN Trial: Reduction in Primary Endpoint With Sequential Macitentan

12. GRIPHON Trial: Reduction in Primary Endpoint With Sequential Selexipag

13. Timing of Combination Therapy

14. AMBITION: Initial Use of Combination Ambrisentan + Tadalafil

15. AMBITION Trial: Reduction in Primary Endpoint With Initial Ambrisentan + Tadalafil

16. AMBITION Trial: First Adjudicated Clinical Failure by Baseline FC

17. Case Presentation (cont)

18. Combination Therapy for the Treatment of PAH: Summary

19. Challenges of Using Combination Therapy in PAH

20. Challenges of Using Combination Therapy in PAH (cont)

21. Challenges of Using Combination Therapy in PAH (cont)

22. Conclusions

23. Abbreviations

24. Abbreviations (cont)