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Published byBerenice Montgomery Modified over 6 years ago
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Multiple Motifs Compete for EB-Dependent Microtubule Plus End Binding
Ishutesh Jain, Phong T. Tran Structure Volume 25, Issue 6, Pages (June 2017) DOI: /j.str Copyright © 2017 Elsevier Ltd Terms and Conditions
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Figure 1 EBs Track MT Plus Ends and Recruit Other +TIPs via Distinct and Competing Binding Motifs (A) Cartoon depicting a polarized MT, with EBs (green dots) preferentially binding to the GTP-cap at the MT plus end. (B) Cartoon of three MT protofilaments composed of αβ-tubulin subunits. The EB dimer binds to adjacent protofilaments in a pocket made by the neighboring GTP-bound tubulin heterodimers. (C) Cartoon of EB depicting different interaction domains: calponin homology (CH) domain, EB homology (EBH) domain, and sites of diverse +TIP binding. Structure , DOI: ( /j.str ) Copyright © 2017 Elsevier Ltd Terms and Conditions
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