1. Hexabrix Key Clinical Review Le Feuvre, 2006
Mid-Year Sales Meeting
Bloomington, IN
July 13th – 17th

2. Hexabrix Key Clinical Review
Title:
Cardiac Events After Low Osmolar Ionic or Isosmolar
NonIonic Contrast Media Utilization in the Current Era
of Coronary Angioplasty
Main Author:
Claude Le Feuvre
Publication:
Catheterization and Cardiovascular Interventions
Date:
2006

3. Hexabrix Key Clinical Review
Study Objective(s):
To compare Visipaque and Hexabrix in the current era of (PCI), using clopidogrel, enoxaparine, direct stenting, and drug eluting stent.

4. Hexabrix Key Clinical Review
Patient Population Details:
498 Consecutive Patients over 6 months
First, third & fifth months patients received Hexabrix (267)
Second, fourth and sixth months patients received Visipaque (231).
No significant difference among baseline characteristics.

5. Hexabrix Key Clinical Review
Primary & Secondary Endpoints:
Primary: The cumulative rate of in-hospital major adverse clinical events (MACE).
Secondary: The rate of angiographic or procedural complications

6. Hexabrix Key Clinical Review
Outcomes & Results:
The primary composite end point occurred less frequently in the Hexabrix group.
By 30 days, the cumulative rate of the primary composite endpoint remained lower in the Hexabrix group.
Thrombus-related events were more frequent with Visipaque than with Hexabrix.

7. Hexabrix Key Clinical Review1 2 3 4 5 6 %
Large thrombus
Target vessel occlusion
Iodixanol
Ioxaglate
p =
p = 0.003

8. Hexabrix Key Clinical Review
Other Important Notes:
All patients received aspirin and enoxaparin.
MACE was defined as cardiac death, recurrent nonfatal acute myocardial infarction, emergency CABG or repeat PCI for documented ischemic ECG changes, stroke, or systemic thromboembolic event.
Clinical outcomes were assessed at hospital discharge and by telephone at 30 days.

9. Hexabrix Key Clinical Review
Role Play (15 min)
Pairs of 3 (MCP, MD & Observer)
Each MCP detail the paper to group
Be sure to summarize the key points

10. Hexabrix Key Clinical Review
Examples of use in the field?