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Value of circulating insulin-like growth factor–associated proteins for the detection of stage I non–small cell lung cancer  John C. Kubasiak, MD, Christopher.

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Presentation on theme: "Value of circulating insulin-like growth factor–associated proteins for the detection of stage I non–small cell lung cancer  John C. Kubasiak, MD, Christopher."— Presentation transcript:

1 Value of circulating insulin-like growth factor–associated proteins for the detection of stage I non–small cell lung cancer  John C. Kubasiak, MD, Christopher W. Seder, MD, Ravi Pithadia, MD, Sanjib Basu, PhD, Cristina Fhied, MS, William W. Phillips, BS, Shaun Daly, MD, David D. Shersher, MD, Mark A. Yoder, MD, Gary Chmielewski, MD, Eric S. Edell, MD, Fabien Maldonado, MD, Michael J. Liptay, MD, Jeffrey A. Borgia, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 149, Issue 3, Pages e3 (March 2015) DOI: /j.jtcvs Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Illustration of the experimental workflow. A, The workflow for the serum-based biomarker evaluation phase. B, The workflow for the plasma-based multianalyte algorithm development. C, The validation phase. Luminex Corp (Austin, Tex). NSCLC, Non–small lung cancer. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Representative box and whisker plots illustrating distributions and differences in biomarkers. Four representative plots are provided to permit an appreciation of serum biomarker distributions between the combined Rush and Mayo cohorts for patients with either a benign nodule (n = 123) or malignant nodule (n = 224). Significance is indicated by a bar with “1” indicating P ≤ .001; “2” meaning P < .01; and “3” meaning P < .05. Not all extreme values are represented on the provided plots. IGF, Insulin-like growth factor; IGFBP, insulin-like growth factor binding protein. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

4 Figure E1 Receiver operator characteristics curves from the multianalyte algorithm validation. Illustrated is the performance of the 7-analyte panel against the Mayo Clinic (ie, validation) cohort. The panel is composed of interleukin (IL)-6, IL-10, IL-1ra, stromal cell-derived factor-1α + β, insulin-like growth factor binding protein-5, and insulin-like growth factor-2. AUC, Area under the curve. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

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