1. PHL 313 (Lab. 6) Effect of Drugs on Rabbit’s Isolated Heart

2. Ringer’s Solution Sodium chloride Potassium chloride Glucose
Sodium bicarbonate
Calcium chloride
Oxygen
Temperature 37 C

3. Heart Rate (HR):Beats/min. Force of contraction.
Parameters
Heart Rate (HR):Beats/min.
Force of contraction.

4. Normal Heart Rate 60-100 beats/ minute
Tachycardia
more than 100 beats/minute
Bradycardia
Less than 60 beats/ minute

5. Drugs Drug HR Force of contraction Epinephrine (beta receptor)
increase
Increase
Norepinephrine (beta receptor)
Propranolol ( beta blocker)
Decrease
Digoxin ( C.H.F)
Procainamide ( anti arrhythmic)
KCL
Verapamil (Ca. Ch. Blocker)