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Myosin Learns to Recruit AMPA Receptors

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Presentation on theme: "Myosin Learns to Recruit AMPA Receptors"— Presentation transcript:

1 Myosin Learns to Recruit AMPA Receptors
Eran Perlson, Erika L.F. Holzbaur  Cell  Volume 135, Issue 3, Pages (October 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Myosin Vb-Dependent AMPA Receptor Trafficking during LTP
During long-term potentiation (LTP), neuronal activation of NMDA receptors leads to a localized influx of Ca2+ at dendritic spines. This influx induces a Ca2+-dependent conformational change in myosin Vb (Wang et al., 2008). The unfolding of myosin Vb exposes a cargo-binding domain, which mediates the recruitment of the motor to the membrane-associated Rab11/effector complex on the recycling endosome. The activated myosin then drives the trafficking of AMPA receptors to synaptic sites, leading to the localized increase in AMPA receptor density characteristic of LTP. Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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