1. Deficiency of MyD88 Signaling in CD4 Tconvs Increases Tregs Suppression through Loss of ST2 Signaling, Reducing Acute Graft-Versus-Host Disease in Multiple Models 
Brad Griesenauer, Abdulraouf Ramadan, Jilu Zhang, Janefrances Egbosiuba, Sophie Paczesny 
Biology of Blood and Marrow Transplantation 
Volume 23, Issue 3, Pages 1-3 (March 2017)
DOI: /j.bbmt
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2. Figure 1
MyD88 knockout CD4 T cells reduces GVHD mortality. Survival curves from mice receiving T cell depleted bone marrow cells and (A) syngeneic, B6WT, or B6 MyD88−/− total T cells, **P < .01, B6 WT total T cells vs B6 MyD88−/− total T cells, (B) syngeneic, B6 WT, or B6 MyD88−/− total T cells, *P < .05, B6 WT total T cells vs B6 MyD88−/− total T cells, (C) syngeneic, B6 WT, or B6 IL-1R−/− total T cells, (D) syngeneic, B6 WT CD4 and MyD88−/− CD8 T cells, or B6 MyD88−/− CD4 and WT CD8 T cells, (E) syngeneic, B6 WT, or B6 MyD88−/− Tconvs w/o Tregs, or (F) syngeneic, B6 WT Tconv w/o Tregs and B6 WT Tregs, or B6 WT Tconv w/o Tregs and B6 MyD88−/− Tregs.
Biology of Blood and Marrow Transplantation  , 1-3DOI: ( /j.bbmt )
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3. Figure 2
Loss of MyD88 in Tconvs increases Treg suppression through loss of Tconv sST2. Survival curves from mice receiving T cell depleted bone marrow cells and (A) WT or MyD88−/− Tconv w/o Tregs and either WT or MyD88−/− Tregs, **P < .01 B6 WT Tconv w/o Treg + MyD88−/− Treg vs MyD88−/− Tconvs w/o Treg + WT Treg, *P < .05 B6 WT Tconv w/o Treg + MyD88−/− Treg vs MyD88−/− Tconvs w/o Treg + MyD88−/− Treg, or (B) WT or ST2−/− Tconv w/o Tregs and either WT or ST2−/− Tregs, *P < .05 B6 WT Tconv w/o Treg + ST2−/− Treg vs ST2−/− Tconvs w/o Treg + WT Treg. (C) Transcriptome analysis of gut WT and MyD88−/− CD4 T cells ten days post-HCT showing decreased transcritp expression levels of genes involoved in type 1 immunity. The kinetics of plasma levels of (D) sST2, *P < .05, day 10, B6 WT Tconv w/o Treg + MyD88−/− Treg vs MyD88−/− Tconvs w/o Treg +WT Treg, and (E) IFN-γ, **P < .01, day 10, B6 WT Tconv w/o Treg + MyD88−/− Treg vs MyD88−/− Tconvs w/o Treg + WT Treg.
Biology of Blood and Marrow Transplantation  , 1-3DOI: ( /j.bbmt )
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