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Differences in secretion of prostacyclin by venous and arterial endothelial cells grown in vitro in a static versus a mechanically active environment 

Published byAdelia Garrett Modified over 6 years ago

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Presentation on theme: "Differences in secretion of prostacyclin by venous and arterial endothelial cells grown in vitro in a static versus a mechanically active environment "— Presentation transcript:

1 Differences in secretion of prostacyclin by venous and arterial endothelial cells grown in vitro in a static versus a mechanically active environment  Gilbert R. Upchurch, BA, Albert J. Banes, PhD, Willis H. Wagner, MD, Fuad Ramadan, MD, Garnett W. Link, PhD, Renee H. Henderson, MA, George Johnson, MD  Journal of Vascular Surgery  Volume 10, Issue 3, Pages (September 1989) DOI: / (89) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

2 Fig. 1 Difference in secretion of PGI2 by venous and arterial ECs (VEC and AEC) isolated from the same animal and grown in a control environment. Cells for this experiment were first-passage cells and were seeded at an initial density of 30,000 cells per well. Data are shown as the mean ± SD (n = six wells per day). A statistically significant increase of PGI2 is seen on day 5, with venous ECs secreting more PGI2 per cell than do arterial ECs. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

3 Fig. 2 Effect of a 60 cycles/min mechanical deformation regimen on the secretion of PGI2 by stretched arterial ECs (AES). For details see text. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

4 Fig. 3 Effect of a 60 cycles/min mechanical deformation regimen on the secretion of PGI2 by stretched venous ECs (VES). For details see text. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

5 Fig. 4 Effect of treating arterial ECs (control and stretch [AEC, AES]) with media that contain 20 μmol/L ibuprofen. For details see text. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

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