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Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury  Robert W. Teasell, MD, J.Malcolm.

Published byJeremy Garrett Modified over 6 years ago

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Presentation on theme: "Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury  Robert W. Teasell, MD, J.Malcolm."— Presentation transcript:

1 Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury  Robert W. Teasell, MD, J.Malcolm O. Arnold, MD, Andrei Krassioukov, MD, PhD, Gail A. Delaney, MD  Archives of Physical Medicine and Rehabilitation  Volume 81, Issue 4, Pages (April 2000) DOI: /mr Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

2 Fig. 1 Haematoxylin/eosin stained sections through (A and B) the first and (C and D) the eighth thoracic segments of human spinal cord (person died 2 weeks after spinal injury). Panels B and D are the areas of intermediolateral nucleus (IML), with sympathetic neurons at higher magnification, that are outlined in panels A and C, respectively. (The IML is the nucleus within the lateral horn of the cord.) A small contusion hemorrhage within the dorsla funiculus is clearly present at T8 level (indicated by arrow on panel C). CC, central canal; T, thoracic level. Calibration line on panel C, for panels A and C, represents 1mm; calibration line on panel D, for panels B and D, represents 200μm. Archives of Physical Medicine and Rehabilitation  , DOI: ( /mr ) Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

3 Fig. 2 Venous responsiveness to local infusion of increasing concentrations of noradrenaline using the dorsal foot vein of 6 quadriplegic patients was compared with 6 age- and sex-matched controls. A significant shift to the left of dose-response curve is seen in quadriplegic patients. The concentration of noradrenaline required to vasoconstrict the dorsal foot vein to half baseline value in quadriplegics (1.6ng/min) was less than controls (10.9ng/min, p <.02). (Reprinted with permission.1) Archives of Physical Medicine and Rehabilitation  , DOI: ( /mr ) Copyright © 2000 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation Terms and Conditions

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