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Cytokine response after severe respiratory syncytial virus bronchiolitis in early life  Mario Castro, MD, MPH, Toni Schweiger, RN, Huiquing Yin-DeClue,

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Presentation on theme: "Cytokine response after severe respiratory syncytial virus bronchiolitis in early life  Mario Castro, MD, MPH, Toni Schweiger, RN, Huiquing Yin-DeClue,"— Presentation transcript:

1 Cytokine response after severe respiratory syncytial virus bronchiolitis in early life 
Mario Castro, MD, MPH, Toni Schweiger, RN, Huiquing Yin-DeClue, PhD, Thiruvamoor P. Ramkumar, PhD, Chandrika Christie, BA, Jie Zheng, Rebecca Cohen, BA, Kenneth B. Schechtman, PhD, Robert Strunk, MD, Leonard B. Bacharier, MD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 4, Pages e3 (October 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 PBMC cytokine expression levels in those with and without asthma. Quantitative analysis of PBMCs by FACS for IL-2, IL-4, IL-13, and IFN-γ in those with physician-diagnosed asthma (gray bars) or not (white bars) in the RBEL cohort from initial infection with RSV (entry) to 2, 4, and 6 years of age. Means ± SEs. ∗P = .001. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 PBMC cytokine expression levels in those with and without eczema. Quantitative analysis of PBMCs by FACS for IL-2, IL-4, IL-13, and IFN-γ in those with eczema (gray bars) or not (white bars) in the RBEL cohort from initial infection with RSV (entry) to 2, 4, and 6 years of age. Means ± SEs. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 PBMC cytokine expression levels in those with and without allergic sensitization. Quantitative analysis of PBMCs by FACS for IL-2, IL-4, IL-13, and IFN-γ in those with eczema (gray bars) or not (white bars) in the RBEL cohort from initial infection with RSV (entry) to 2, 4, and 6 years of age. Means ± SEs. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Bland-Altman plots of PBMC cytokine expression levels measured by flow cytometry and real-time PCR in the RBEL cohort children at 2 years of age for IFN-γ (A), IL-2 (B), IL-4 (C), and IL-13 (D). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Bland-Altman plots of PBMC cytokine expression levels measured by flow cytometry and real-time PCR in the RBEL cohort children at 4 years of age for IFN-γ (A), IL-2 (B), IL-4 (C), and IL-13 (D). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Bland-Altman plots of PBMC cytokine expression levels measured by flow cytometry and real-time PCR in the RBEL cohort children at 6 years of age for IFN-γ (A), IL-2 (B), IL-4 (C), and IL-13 (D). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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