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Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways  Anthony J. Frew, MD, Johanne St-Pierre,

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Presentation on theme: "Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways  Anthony J. Frew, MD, Johanne St-Pierre,"— Presentation transcript:

1 Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways  Anthony J. Frew, MD, Johanne St-Pierre, PhD, Luis M. Teran, MD, PhD, Alexandre Trefilieff, PhD, Jacqueline Madden, MPhil, Diego Peroni, MD, Kathleen M. Bodey, BSc, Andrew F. Walls, PhD, Peter H. Howarth, DM, Mary P. Carroll, MD, Stephen T. Holgate, MD  Journal of Allergy and Clinical Immunology  Volume 98, Issue 1, Pages (July 1996) DOI: /S (96)70235-X Copyright © 1996 Mosby, Inc. Terms and Conditions

2 FIG. 1 CD3+ T-cell numbers in blood before and 24 hours after challenge (A) and in the BAL samples obtained 24 hours after allergen or saline segmental challenge (B). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 FIG. 1 CD3+ T-cell numbers in blood before and 24 hours after challenge (A) and in the BAL samples obtained 24 hours after allergen or saline segmental challenge (B). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 FIG. 2 Numbers of mast cells, eosinophils, and neutrophils per square millimeter in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 FIG. 2 Numbers of mast cells, eosinophils, and neutrophils per square millimeter in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 FIG. 2 Numbers of mast cells, eosinophils, and neutrophils per square millimeter in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

9 FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

10 FIG. 3 Number of cells per square millimeter expressing CD3, CD4, CD8, or CD25 in bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

11 FIG. 4 Bronchial biopsy specimens showing endothelial staining for the adhesion molecules P-selectin (A) and ICAM-1 (B) 24 hours after local allergen challenge. (Original magnification ×400.) Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

12 FIG. 4 Bronchial biopsy specimens showing endothelial staining for the adhesion molecules P-selectin (A) and ICAM-1 (B) 24 hours after local allergen challenge. (Original magnification ×400.) Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

13 FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

14 FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

15 FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

16 FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

17 FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

18 FIG. 5 Percentage of small blood vessels expressing ICAM-1, P-selectin, E-selectin, or VCAM-1 and the numbers of cells per square millimeter expressing LFA-1 or VLA-4 in the bronchial submucosa after allergen or saline challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96)70235-X) Copyright © 1996 Mosby, Inc. Terms and Conditions

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