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Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms,

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Presentation on theme: "Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms,"— Presentation transcript:

1 Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms, and sporadic aneurysms  Rumin He, MD, Dong-Chuan Guo, PhD, Wei Sun, PhD, Christina L. Papke, BS, Senthil Duraisamy, PhD, Anthony L. Estrera, MD, Hazim J. Safi, MD, Chul Ahn, PhD, L. Maximilian Buja, MD, Frank C. Arnett, MD, Jingwu Zhang, MD, Yong-Jian Geng, MD, PhD, Dianna M. Milewicz, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 136, Issue 4, Pages e1 (October 2008) DOI: /j.jtcvs Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Immunohistochemistry for markers of immune cells in the media and adventitia of aortas from controls and patients with MFS, FTAA, and TAA. The marker recognized by the antibody used for immunohistochemistry, the segment of the aorta photographed, and the magnification are on the left. The cause of the aneurysm is on the top. The orientation in the photographs is the lumen of the aorta at the bottom and the adventitia at the top. Color was developed with DAB for peroxidase (brown) or Fast Red for alkaline phosphatase (red). Magnification 200× for panels except CD3 adventitia staining. MFS, Marfan syndrome; FTAA, familial thoracic aortic aneurysm; TAA, thoracic aortic aneurysm. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Morphometric quantization of lymphocytes, subpopulations of T cells, and macrophages in ascending aortas of controls and patients with MFS, FTAA, and TAA. After immunohistochemistry of aortic tissue, CD3, CD4, CD8, CD20, and CD68-positive cells in the media in 10 contiguous high-power fields (magnification 400×) were counted by 2 independent observers. In the aortas of patients with MFS, FTAA, and TAA, there was a significant increase in the number of CD3+, CD4+, CD8+, CD20+, and CD68+ cells when compared with control aortas (∗P < .01). MFS, Marfan syndrome; FTAA, familial thoracic aortic aneurysm; TAA, thoracic aortic aneurysm. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Increased expression of leukocyte adhesion molecules, ICAM-1, and VCAM-1 in the vasa vasorum in the adventitia of patients with MFS and FTAA. Immunohistochemistry revealed positive immunostaining for ICAM-1 and VCAM-1 in the vasa vasorum from patients with MFS and FTAA. Magnification 400×. MFS, Marfan syndrome; FTAA, familial thoracic aortic aneurysm; ICAM, intercellular adhesion molecule; VCAM, vascular cell adhesion molecule. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Inverse correlation between the age of patients at the time of prophylactic repair of the aorta and the number of T lymphocytes (CD3+ staining) and macrophages (CD68+ staining) in the aortic media of patients. CD3+ cells (A) and CD68+ cells (B) were counted in 10 contiguous high-power fields of the aortic media of TAAs from 19 patients with MFS, FTAA, and sporadic TAA. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

6 TCR BV gene distribution profiles in the aortas of controls and patients with MFS, FTAA, TAA, and sporadic TAA, and in peripheral blood mononuclear cells of patients with MFS and TAA. TCR BV gene expression was analyzed quantitatively using RNA from aortic tissue and peripheral blood mononuclear cells by real-time PCR using specific primers for 25 BV genes. BV gene distribution is presented as the mean percentage expression of each BV gene relative to BC expression on the y axis. MFS, Marfan syndrome; FTAA, familial thoracic aortic aneurysm; TAA, thoracic aortic aneurysm; CTL, control; PBMC, peripheral blood mononuclear cell. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

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