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Zebrafish Reel in Phenotypic Suppressors of Autism

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Presentation on theme: "Zebrafish Reel in Phenotypic Suppressors of Autism"— Presentation transcript:

1 Zebrafish Reel in Phenotypic Suppressors of Autism
Jakob Biran, Gil Levkowitz  Neuron  Volume 89, Issue 4, Pages (February 2016) DOI: /j.neuron Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Behavioral Drug-Effect Profiling Reveals Phenotypic Suppressors of cntnap2 Mutant (A) The CNTNAP2 gene is linked to ASD in human. Zebrafish cntnap2 mutants display heightened nighttime activity (Hoffman et al., 2016). (B) Quantitative behavioral profiling of wild-type zebrafish larvae treated with a collection of psychoactive compounds identifies small molecules that phenocopy the cntnap2 mutant phenotype (correlating) as well as compounds eliciting a behavioral signature opposite to that of mutant larvae (anti-correlating). This screen showed that molecules with estrogen-like activity suppress the cntnap2 mutant phenotype. Neuron  , DOI: ( /j.neuron ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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