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Leishmania Dices Away Cholesterol for Survival

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1 Leishmania Dices Away Cholesterol for Survival
Albert Descoteaux, Neda Moradin, Guillermo Arango Duque  Cell Host & Microbe  Volume 13, Issue 3, Pages (March 2013) DOI: /j.chom Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 GP63 Disrupts Cholesterol Metabolism through DICER1 Cleavage
In hepatocytes of a noninfected liver, pri-miR-122 in the nucleus is processed by Drosha into pre-miR-122, which is then transported to the cytoplasm. Pre-miR-122 is further processed by DICER1 and AGO2 into mature miR-122, thence forming miRNP-122. This ribonucleoprotein regulates many enzymes that modulate cholesterol metabolism. During Leishmania infection, hepatocytes internalize exosomes containing the parasite metalloprotease GP63, which cleaves DICER1, leading to an accumulation of pre-miR-122. The consequential disruption in cholesterol metabolism ensues in hypocholesterolemia. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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