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Thomas L. Gentles, FRACPa. , John E

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1 Fontan operation in five hundred consecutive patients: Factors influencing early and late outcome 
Thomas L. Gentles, FRACPa*, John E. Mayer, Jr, MDb, Kimberlee Gauvreau, ScDa, Jane W. Newburger, MD, MPHa, James E. Lock, MDa, John P. Kupferschmid, MDb**, Janice Burnett a, Richard A. Jonas, MDb, Aldo R. Castañeda, MD, PhDb, Gil Wernovsky, MDa***  The Journal of Thoracic and Cardiovascular Surgery  Volume 114, Issue 3, Pages (September 1997) DOI: /S (97) Copyright © 1997 Mosby, Inc. Terms and Conditions

2 Fig. 1 Diagnostic groups by operation year. Each time period represents approximately one quarter of the 500 patients. LV-NRGA, Morphologically left ventricle with normally related great vessels; LV-TGA, morphologically left ventricle with transposition of the great arteries; Heterotaxy, heterotaxy syndrome; Single RV, morphologically right ventricle or ventricle of undetermined morphology; HLHS, hypoplastic left heart syndrome; Other, Other diagnoses (see text for details). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

3 Fig. 2 Early failure by year of operation and diagnostic grouping. Abbrevations as for Fig. 1. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

4 Fig. 3 Estimated probability of early failure by age at Fontan operation for the total group (A) and for those with and without baffle fenestration (B). Point estimates and exact 95% confidence intervals for outcome probabilities are plotted for the means of the age groups categorized as less than 4 years, 4 to 15 years, and 16 years or greater. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

5 Fig. 3 Estimated probability of early failure by age at Fontan operation for the total group (A) and for those with and without baffle fenestration (B). Point estimates and exact 95% confidence intervals for outcome probabilities are plotted for the means of the age groups categorized as less than 4 years, 4 to 15 years, and 16 years or greater. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

6 Fig. 4 The probability of survival with a Fontan circulation with time zero as the time of the Fontan operation. Patients who did not experience a failure of the Fontan circulation (death, takedown, or cardiac transplantation) were censored at the time of last follow-up. A , Kaplan-Meier estimates with Greenwood confidence bands for the entire group of 500 patients. Numbers are sample size at 4-year intervals. B , Kaplan-Meier estimates of the probability of survival with a Fontan circulation by year of operation for the first 5 years of follow-up. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

7 Fig. 4 The probability of survival with a Fontan circulation with time zero as the time of the Fontan operation. Patients who did not experience a failure of the Fontan circulation (death, takedown, or cardiac transplantation) were censored at the time of last follow-up. A , Kaplan-Meier estimates with Greenwood confidence bands for the entire group of 500 patients. Numbers are sample size at 4-year intervals. B , Kaplan-Meier estimates of the probability of survival with a Fontan circulation by year of operation for the first 5 years of follow-up. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

8 Fig. 5 Kaplan-Meier estimates of the probability of late survial with a Fontan circulation as a function of diagnosis. Time zero is 30 days after the Fontan operation. LV-NRGA, Left ventricle with normally related great vessels; Single RV/?V, single right ventricle or ventricle with unknown morphology. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

9 Fig. 6 Kaplan-Meier estimates of the probability of late survial with a Fontan circulation in patients with and without a pacemaker before the Fontan operation. Time zero is 30 days after the Fontan operation. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

10 Fig. 7 Estimated probability of early failure as a function of age at the Fontan operation by year of operation. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

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