1. Structure and function of the retinoic acid receptor alpha gene and protein upon binding of RA
Figure 1 from T Schenk et al.
British Journal of Cancer Advance Online Publication
20 November 2014 doi: /bjc
Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies.
© 2014 Cancer Research UK.