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IL-22 Directly Regulates Intestinal Stem Cells, Protecting Epithelium from GvHD and Reducing GvHD Mortality  Caroline A. Lindemans, MD, PhD, Anna Mertelsmann,

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Presentation on theme: "IL-22 Directly Regulates Intestinal Stem Cells, Protecting Epithelium from GvHD and Reducing GvHD Mortality  Caroline A. Lindemans, MD, PhD, Anna Mertelsmann,"— Presentation transcript:

1 IL-22 Directly Regulates Intestinal Stem Cells, Protecting Epithelium from GvHD and Reducing GvHD Mortality  Caroline A. Lindemans, MD, PhD, Anna Mertelsmann, Margaret O'Connor, Marco Calafiore, Jarrod A. Dudakov, Robert Jenq, MD, Enrico Velardi, Lauren Young, Odette M. Smith, BA, Gillian Lawrence, Natalie Luo, Juliet Ivanov, Guoqiang Hua, Laura Martin, Chen Liu, Richard Kolesnick, Marcel R.M. van den Brink, MD, PhD, Alan M. Hanash, MD, PhD  Biology of Blood and Marrow Transplantation  Volume 21, Issue 2, Pages S58-S59 (February 2015) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 IL-22 induces epithelial regeneration ex vivo.
Biology of Blood and Marrow Transplantation  , S58-S59DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 ISCs are expanded by IL-22 in vitro.
Biology of Blood and Marrow Transplantation  , S58-S59DOI: ( /j.bbmt ) Copyright © Terms and Conditions

4 Figure 3 In vivo administration of F-652 (rhlL-22) rescues mice from GVHD. Biology of Blood and Marrow Transplantation  , S58-S59DOI: ( /j.bbmt ) Copyright © Terms and Conditions

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