1. COMBINATIONS AND COFORMULATIONS: THE FUTURE OF INSULIN THERAPY?

2. Insulin Therapy in T2DM

3. Agenda

4. ADA/EASD Recommendations for T2DM Management: The Role of Injectables

5. Intensification Options for Insulin Therapy

6. Complementary Effects of Basal Insulin and GLP-1 RA Therapy

7. Complementary Actions of GLP-1 RA and Insulin

8. Fixed-Ratio Combinations of Basal Insulin and GLP-1 RAs

9. IGlarLixi Proof-of-Concept Study

10. IDegLira Fixed-Ratio Combination Dosing Regimen

11. IDegLira in Insulin-Naive T2DM Patients Study Design: DUAL I

12. IDegLira in Insulin-Naive T2DM Patients: Glycemic Control

13. IDegLira in Insulin-Naive T2DM Patients: Glycemic Control (cont)

14. IDegLira in Insulin-Naive T2DM Patients: Weight

15. IDegLira in Insulin-Naive T2DM Patients: Hypoglycemia

16. IDegLira in Insulin-Naive T2DM Patients: Nausea

17. Practical Aspects of Using Fixed-Ratio Basal Insulin/GLP-1 RA Combinations

18. Conclusions

19. Abbreviations

20. Abbreviations (cont)