1. Inflammation Joins the “Niche”
Héctor Peinado, Shahin Rafii, David Lyden 
Cancer Cell 
Volume 14, Issue 5, Pages (November 2008)
DOI: /j.ccr
Copyright © 2008 Elsevier Inc. Terms and Conditions

2. Figure 1 The Premetastatic Niche Is Similar to an Inflammatory Nidus
Both S100A8 and S100A9 induce the expression of SAA3 specifically in future metastasis sites in the lung, promoting Mac1+ myeloid and endothelial cell engraftment. In this process, SAA3 promotes its own secretion by a positive feedback mechanism mediated by TLR4 and induces NF-κB signaling pathway activation (left). This inflammation-like state accelerates the future recruitment of tumor cells (right).
Cancer Cell  , DOI: ( /j.ccr )
Copyright © 2008 Elsevier Inc. Terms and Conditions