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Fig. 6. Safety assessment in cynomolgus monkey.

Published bySudirman Susman Modified over 6 years ago

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Presentation on theme: "Fig. 6. Safety assessment in cynomolgus monkey."— Presentation transcript:

1 Fig. 6. Safety assessment in cynomolgus monkey.
Safety assessment in cynomolgus monkey. (A) Binding affinity of ERY974 to human or cynomolgus monkey epitope peptides derived from GPC3 or CD3 was measured by surface plasmon resonance analysis. KD, dissociation constant. (B) Change in serum interleukin (IL)–6 concentration over time in a single-dose study. Five animals per sex per group received a single administration of ERY974. Necropsies were performed on day 22 after the dose. (C) Serum IL-6 concentration (red and black lines) over time in a repeated-dose study. Three animals per sex received doses (blue bars) that increased daily by about threefold to 1.5 mg/kg. Necropsies were performed on day 10. Takahiro Ishiguro et al., Sci Transl Med 2017;9:eaal4291 Published by AAAS

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