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Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin- clavulanate and piperacillin-tazobactam with extended-spectrum.

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Presentation on theme: "Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin- clavulanate and piperacillin-tazobactam with extended-spectrum."— Presentation transcript:

1 Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin- clavulanate and piperacillin-tazobactam with extended-spectrum β-lactamase-producing and extended-spectrum β-lactamase-non-producing Escherichia coli isolates.  L. López-Cerero, E. Picón, C. Morillo, J.R. Hernández, F. Docobo, J. Pachón, J. Rodríguez-Bañ, A. Pascual  Clinical Microbiology and Infection  Volume 16, Issue 2, Pages (February 2010) DOI: /j x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG 1 Time-kill curves of E. coli ATCC at high inoculum for AMC (a) and PTZ (b); and time-kill curves of ESBL-producers at standard inoculum with 8 × AMC MIC (c) and × 8 PTZ MIC (d), and at high inoculum with 8 × AMC MIC (e) and 8 × PTZ MIC (f). Filled diamonds, CTX-M-14-producing strain; open squares, TEM-3-producing strain; open circles, SHV-12-producing strain; double cross, 2 × MIC; cross, 4 × MIC; cross, 8 × MIC; broken line, lower limit of detection. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions


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