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Spread of a new Chlamydia trachomatis variant from men who have sex with men to the heterosexual population after replacement and recombination in ompA.

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Presentation on theme: "Spread of a new Chlamydia trachomatis variant from men who have sex with men to the heterosexual population after replacement and recombination in ompA."— Presentation transcript:

1 Spread of a new Chlamydia trachomatis variant from men who have sex with men to the heterosexual population after replacement and recombination in ompA and pmpH genes  M. Rodríguez-Domínguez, J.M. González-Alba, T. Puerta, L. Martínez-García, B. Menéndez, R. Cantón, J. del Romero, J.C. Galán  Clinical Microbiology and Infection  Volume 23, Issue 10, Pages (October 2017) DOI: /j.cmi Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

2 Fig. 1 (a) Temporal evolution of Chlamydia trachomatis strains carrying the recombinant pmpH gene during the periods of time described. The pmpH-recombinant variant was detected by PCR on direct sample. (b) Annual detection of pmpH-recombinant C. trachomatis strains depending on from where the samples were taken. Solid colours represent the recombinant variant and striped colours correspond to the non-recombinant variant. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

3 Fig. 2 Distribution of symptomatic and asymptomatic Chlamydia trachomatis infections carrying pmpH-recombinant gene, depending on the type of the sample. Co-STD, co-infections caused by C. trachomatis and other sexually transmitted diseases simultaneously, in this series all cases were Neisseria gonorrhoeae. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

4 Fig. 3 (a) Maximum likelihood (ML) phylogeny of pmpH gene from Chlamydia trachomatis. The different pathotypes are easily differentiated (bootstrap ≥99). This phylogenetic tree was performed with all pmpH sequences available in GenBank. (b) ML phylogeny of five concatenated genes (pmpH, rs2, lysS, incE-F and ompA). Those sequences with detected recombinant events in this gene are shown in bold. The red bold sequences correspond to a recombinant closely related to pmpH found in Madrid, whereas light blue represents the recombinant variants detected in Seattle. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

5 Fig. 4 Bayesian analysis of concatenated genes. Using strains belonging to recombinant pmpH variants from Madrid, non-recombinant genes were concatenated and phylogenies were obtained using a Bayesian Markov chain Monte Carlo method implemented in BEAST v program. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions


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