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Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries 

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Presentation on theme: "Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries "— Presentation transcript:

1 Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries  Offer Galili, MD, Katherine J. Sattler, MD, Joerg Herrmann, MD, Julie Woodrum, MS, Monica Olson, BS, Lilach O. Lerman, MD, PhD, Amir Lerman, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 129, Issue 4, Pages (April 2005) DOI: /j.jtcvs Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Representative micro-CT images of the coronary artery and the left internal thoracic artery (LITA) of pigs maintained on a normal diet (N) and a high-cholesterol diet (HC) for 12 weeks. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Correlation between second-order/first-order VV ratio and VV density in the coronary artery and the left internal thoracic artery (LITA) of pigs maintained on normal diet (N) and a high-cholesterol diet (HC) for 12 weeks. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Enzyme-linked immunosorbent assay for VEGF in the coronary artery and left internal thoracic artery (LITA) of pigs maintained on a normal diet (N) and a high-cholesterol diet (HC) for 12 weeks. An increase in VEGF expression in both vascular beds in response to the HC diet is observed. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Immunohistochemistry for NF-κB (subunit p65). NF-κB is localized in the endothelial cells (black arrows) and in the adventitia (white arrows) of both vessels from pigs receiving a high-cholesterol diet. Vessels from pigs receiving a normal diet showed minimal staining for NF-κB. The left internal thoracic artery (LITA) contains a large number of elastic laminae in its media (black double-headed arrows) and few smooth muscle fibers, whereas the coronary artery contains a high amount of smooth muscle fibers (white double-headed arrows) and few elastic laminae. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions


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