1. Caspase-8, Death-Receptor Signaling, and Hepatocarcinogenesis: The Fas and the Furious 
Edwina S. Baskin–Bey, Gregory J. Gores 
Gastroenterology 
Volume 129, Issue 5, Pages (November 2005)
DOI: /j.gastro
Copyright © 2005 American Gastroenterological Association Terms and Conditions

2. Figure 1
Speculation of the role of caspase-8 silencing in hepatocarcinogenesis. Death-receptor-mediated caspase-8 activation results in apoptosis and cell death. If the caspase-8 promoter is methylated inhibiting SP1 binding and transactivation then cellular fates are switched to that of tumorigenesis, potentially secondary to potentiating the Fas/NF-κB pathway (dashed line). If histone deacetylases (HDAC) or methylase inhibitors are used in this model then the fate of tumor cells can be reversed back to that of cell death.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions