1. Relative protein levels
WT /-
75 KDa
ABC-me
50 KDa
Actin
37 KDa
50 KDa
75 KDa
37 KDa
0.2
0.4
0.6
0.8 1
1.2
1.4 WT
+/-
-/-
Relative protein levels
(ABC-me / Porin) ND
WT / /-
ABC-me
Porin
Unspecific
band
BCL-xL
Mfrn1
WT ABC-me -/ ABC-me +/-
Porin
37 KDa
0.2
0.4
0.6
0.8 1
1.2
1.4
Porin
Mfrn1
BCL-xL
Relative protein levels WT
ABC-me +/-
ABC-me -/- ND
Figure S1

2. ABC-me -/-
DAPI
Caspase 3
DAPI
Annexin V
Figure S2

3. Figure S3 % change in hemoglobin levels (NAC/vehicle) WT ABC-me +/-
120
100 80
% change in hemoglobin levels (NAC/vehicle) 60 40 20 WT
ABC-me +/-
ABC-me -/-
Figure S3

4. WT ABC-me +/- ABC-me -/- Figure S4 * # CD71 +++ CD71 ++ CD71 +
200
400
600
800
1000
1200
1400
1600
1800
CD71 +++
CD71 ++
CD71 +
Cell population
Mean Fluorescence # *
Figure S4