1. Friday Harbor Laboratory University of Washington August 27-31, 2006
Advanced Psychometric Workshop Composite Measures and Longitudinal Change
Friday Harbor Laboratory
University of Washington
August 27-31, 2006
Friday Harbor Psychometrics Workshop 2006

2. Model Derived Cognitive Trajectories for Hypothetical Cases
Friday Harbor Psychometrics Workshop 2006

3. Model Derived Cognitive Trajectories for Hypothetical Cases
Friday Harbor Psychometrics Workshop 2006

4. Model Derived Cognitive Trajectories for Hypothetical Cases
Friday Harbor Psychometrics Workshop 2006

5. Neuropsychological Test Battery
MAS List Learning Test
WMS-R Digit Span
WMS-R Visual Span
Biber Visual Learning Test
Finger Tapping Test
Token Test
FAS Test
Animal Category Fluency
Boston Naming Test
Benton Form Discrimination Test
Mattis Dementia Rating Scale
Stroop Test
Friday Harbor Psychometrics Workshop 2006

6. Friday Harbor Psychometrics Workshop 2006

7. Background Neuropsychological tests of cognition are commonly used
Research and clinical
Advantages
Standardization
Measurement of areas important to brain pathologies/diseases
Batteries often lengthy with many tests
Friday Harbor Psychometrics Workshop 2006

8. Problems with Comprehensive Batteries
Overwhelming numbers of variables (Mungas factor)
Clinical - How do you integrate multiple, differing measures
Research - How do you distill multiple results into a coherent “story”
Psychometric limitations
Tests may be unsuitable for longitudinal studies due to floor and ceiling effects
Friday Harbor Psychometrics Workshop 2006

9. Mini Mental State Exam Test Characteristic Curve
Friday Harbor Psychometrics Workshop 2006

10. Psychometrics to the Rescue
Can help to identify parsimonious dimensions
In conceptual/empirical context
Can evaluate basic psychometric properties of measures
A test is more than “reliable and valid”
Can be used to create composite measures
Conceptually relevant domains
Desired psychometric properties
Friday Harbor Psychometrics Workshop 2006

11. Mattis DRS Test Characteristic Curve
Friday Harbor Psychometrics Workshop 2006

12. Global Cogn Test Characteristic Curve
Friday Harbor Psychometrics Workshop 2006

13. Test Information Curves for Mattis Dementia Rating Scale and IRT Derived Scales
Friday Harbor Psychometrics Workshop 2006

14. Longitudinal Analysis
Longitudinal study designs have major substantive advantages in research
Come at a cost
Resource intensive data collection
Complicated data analysis
Can directly answer questions that cross sectional studies indirectly address
e.g. relationship between brain change and cognitive change
Friday Harbor Psychometrics Workshop 2006

15. Overview of Workshop Overall Theme
Composite measures of cognition for longitudinal studies
Psychometric methods for creating and evaluating composite measures
Covariance structure analysis/structural equation modeling
Item Response Theory
Longitudinal analysis methods
Friday Harbor Psychometrics Workshop 2006

16. Dataset
Subcortical Ischemic Vascular Dementia Program Project Grant (AG12435)
Helena Chui - PI
Longitudinal neuropsychological assessment
Longitudinal volumetric MRI
Neuropathology
Functional neuroimaging (PET)
Friday Harbor Psychometrics Workshop 2006

17. References
Mungas, D., Reed, B. R., & Kramer, J. H. (2003). Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older persons. Neuropsychology, 17(3),
Mungas, D., Harvey, D., Reed, B. R., Jagust, W. J., DeCarli, C., Beckett, L., et al. (2005). Longitudinal volumetric MRI change and rate of cognitive decline. Neurology, 65(4),
Friday Harbor Psychometrics Workshop 2006

18. Schedule Sunday Evening Introduction and Overview
Friday Harbor Psychometrics Workshop 2006

19. Schedule Monday AM Neuropsychology, neuroimaging, and dementia
SIVD PPG scientific summary
SIVD Overview
Monday Afternoon
IRT Basics
Parscale
Monday Evening
Mplus
Friday Harbor Psychometrics Workshop 2006

20. Schedule Tuesday AM Longitudinal analysis
Overview, methods, missing data
Tuesday PM
SAS and Stata
Tuesday Evening
Mplus
Friday Harbor Psychometrics Workshop 2006

21. Schedule Wednesday Morning Free Afternoon Workgroups Evening
Workgroups, discussion
Friday Harbor Psychometrics Workshop 2006

22. Schedule Thursday Morning Wrap-up Ferry
Friday Harbor Psychometrics Workshop 2006