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Jekyll & Hyde: Evolution of a Superfamily

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Presentation on theme: "Jekyll & Hyde: Evolution of a Superfamily"— Presentation transcript:

1 Jekyll & Hyde: Evolution of a Superfamily
Susan A. Martinis, Yan Ling Joy Pang  Chemistry & Biology  Volume 14, Issue 12, Pages (December 2007) DOI: /j.chembiol Copyright © 2007 Elsevier Ltd Terms and Conditions

2 Figure 1 Evolution of the tRNA Synthetase Superfamily
Mutations confer new functions to a tRNA synthetase. Disease-causing mutations may affect either the protein synthesis activity of the tRNA synthetase or its alternate functions. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2007 Elsevier Ltd Terms and Conditions

3 Figure 2 Non-canonical activities of tRNA synthetases
(A) The tRNA synthetases may be adapted for dual roles that coexist with their aminoacylation activity. (B) Paralogs of tRNA synthetases and their domains can provide important nonaminoacylation functions within the cell. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2007 Elsevier Ltd Terms and Conditions


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