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Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants
Adam S. Himebauch, MD, Susan C. Nicolson, MD, Martha Sisko, BSN, RN, MS, CCRC, Ganesh Moorthy, PhD, Stephanie Fuller, MD, J. William Gaynor, MD, Athena F. Zuppa, MD, MSCE, Elizabeth Fox, MD, Todd J. Kilbaugh, MD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 6, Pages (December 2014) DOI: /j.jtcvs Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions
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Figure 1 Semilogarithmic concentration time profile for unbound cefazolin in plasma of all subjects referenced from the initiation of cardiopulmonary bypass (CPB). The horizontal lines indicate the various concentration targets and associated surgical site infection pathogens. The vertical line indicates the initiation of CPB. DHCA, Deep hypothermic circulatory arrest; E coli, Escherichia coli; K pneumonia, Klebsiella pneumonia; S epidermidis, Staphylococcus epidermidis; MSSA, methicillin-sensitive Staphylococcus aureus. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions
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Figure 2 Semilogarithmic concentration time profile for unbound cefazolin in skeletal muscle of all subjects referenced from the initiation of cardiopulmonary bypass (CPB). The horizontal lines indicate the various concentration targets and associated surgical site infection pathogens. The vertical line indicates the initiation of CPB. DHCA, Deep hypothermic circulatory arrest; E coli, Escherichia coli; K pneumonia, Klebsiella pneumonia; S epidermidis, Staphylococcus epidermidis; MSSA, methicillin-sensitive Staphylococcus aureus. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions
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