1. Supplemental Table 1 Toxicity Liver Kidney AST [IU/L] ref (54-269)
AST [IU/L]
ref (54-269)
ALT [IU/L]
ref (26-77)
BUN [mg/dL]
ref (12-28)
Control
8515
172
223
Met [1 mg/kg]
189117
3515
307
Mito-Met10 [1 mg/kg]
8916
2610
274

2. Supplemental Figure 1

3. Supplemental Figure 2

4. Supplemental Figure 3 A B C

5. Supplemental Figure 4
Mito-Met10
Dec-TPP+

6. Supplemental Figure 5 A Mito-Met2 B Mito-Met6 Day 0 Day 1 Day 2 Day 3
Control
0 M
12.5 M
25 M
50 M A
Mito-Met2
Day 0
Day 1
Day 2
Day 3
Day 4
Day 6
Control
0 M
7.5 M
15 M
30 M B
Mito-Met6

7. Supplemental Figure 6

8. Supplemental Figure 7

9. Supplemental Figure 8 Model setup Mito-Met10 Metformin MiaPaCa-2
PANC-1
OCR (% of control basal)
HPNE
IEC-6

10. Supplemental Figure 9 A B C

11. Supplemental Figure 10

12. Supplemental Figure 11