1. Factors independently associated with odds of fractures
Adjusted odds ratio (95% CI)
No warfarin
Reference group
<1-y warfarin therapy
1.03 ( )
>1-y warfarin therapy
1.25 ( )
Men (>1-y warfarin therapy)
1.63 ( )
Women (>1-y warfarin therapy)
1.05 ( )
Warfarin use on discharge*
0.95 ( )
Age (10-year increase)
1.63 ( )
African American race
0.30 ( )
*Forced into model to prevent confounding
Gage BF et al. Arch Intern Med 2006; 166:
Long-term use of warfarin increases risk of fracture in men [Rheumawire > News; Jan 27, 2006

2. Factors independently associated with odds of fractures
Adjusted odds ratio (95% CI)
No warfarin
Reference group
Male sex
0.54 ( )
Beta-blocker use
0.84 ( )
Heart failure
0.86 ( )
High fall risk
1.78 ( )
Hyperthyroidism
1.77 ( )
Neuropsychiatric impairment
1.51 ( )
Alcoholism
1.50 ( )
Corticosteroid use*
1.24 ( )
*Forced into model to prevent confounding
Gage BF et al. Arch Intern Med 2006; 166:
Long-term use of warfarin increases risk of fracture in men [Rheumawire > News; Jan 27, 2006