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Melatonin Lulling Th17 Cells to Sleep

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Presentation on theme: "Melatonin Lulling Th17 Cells to Sleep"— Presentation transcript:

1 Melatonin Lulling Th17 Cells to Sleep
Jacob S. Lee, Daniel J. Cua  Cell  Volume 162, Issue 6, Pages (September 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Melatonin Shifts the Balance from Th17 to Tr1
(A) Depicted is a schematic of the melatonin signaling pathway resulting in the inhibition of Rorc. (1) Melatonin signals through the melatonin receptor MTNR1A and results in ERK 1/2 phosphorylation. (2) Phosphorylated ERK 1/2 activates the transcription factor C/EBPα (3) and represses the expression of Nr1d1 (REV-ERBα). (4) NR1D1 represses the transcription of Nfil3, which is a (5) repressor of Rorc. Thus, melatonin signaling releases the inhibition of Nfil3 by NR1D1 and results in the suppression of Rorc. (B) A representation of various environmental cues regulating the balance between proinflammatory Th17 cells and immunosuppressive Treg/Tr1 cells. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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