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Association Between Proton Pump Inhibitor Therapy and Clostridium difficile Infection in a Meta-Analysis  Abhishek Deshpande, Chaitanya Pant, Vinay Pasupuleti,

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Presentation on theme: "Association Between Proton Pump Inhibitor Therapy and Clostridium difficile Infection in a Meta-Analysis  Abhishek Deshpande, Chaitanya Pant, Vinay Pasupuleti,"— Presentation transcript:

1 Association Between Proton Pump Inhibitor Therapy and Clostridium difficile Infection in a Meta-Analysis  Abhishek Deshpande, Chaitanya Pant, Vinay Pasupuleti, David D.K. Rolston, Anil Jain, Narayan Deshpande, Priyaleela Thota, Thomas J. Sferra, Adrian V. Hernandez  Clinical Gastroenterology and Hepatology  Volume 10, Issue 3, Pages (March 2012) DOI: /j.cgh Copyright © 2012 AGA Institute Terms and Conditions

2 Figure 1 Study selection process.
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

3 Figure 2 Funnel plot to assess publication bias.
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

4 Figure 3 Overall analysis stratified by study design (all studies).
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

5 Figure 4 (A) Subgroup analysis of case-control studies by percentage of antibiotic use as defined in all the population (CDI + no CDI). (B) Subgroup analysis of case-control studies by percentage of antibiotic use with studies with no information for antibiotic use excluded. (C) Subgroup analysis of case-control studies by percentage of antibiotic use as defined in the CDI group (ie, cases only). (D) Subgroup analysis excluding 4 studies that evaluated recurrent CDI. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions


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