1. Fecal Calprotectin and Lactoferrin
Indicators of inflammatory bowl disease
Fecal Calprotectin and Lactoferrin
P000252
Introduction
The calprotectin (calcium-binding protein) and the lactoferrin (iron binding glycoprotein) are produced primarily by neutrophils. Activation of the intestinal immune system result in activation of neutrophils, which leads to release of both proteins, result in excretion in the feces.
Clinical Information
The main usage of the calprotectin is for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS), when used in conjunction with other diagnostic modalities, including imaging, endoscopy, and histopathology.
Other causes of abnormal calprotectin except IBD
Infections
(Bacterial and viral gastroenteritis)
Malignancies
Drugs
(NSAID, proton pump inhibitors)
Other GI disease
(GERD, cystic fibrosis, LC…)
Other
(Food allergy, Young age < 5 years)
Suspicious IBD
Fecal calprotectin or
lactoferrin + -
Endoscopy - +
Evaluation for
other etiologies
IBD treatment
Test information
Test Name
Test Code
Price
Specimen
Method
TAT
CALPROTECTIN & LACTOFERRIN, FECES
P000252
RS.2,520
FECES
ICT
5 hrs.