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Comparative Evaluation of Broad-Panel PCR Assays for the Detection of Gastrointestinal Pathogens in Pediatric Oncology Patients  Zhengming Gu, Haiqing.

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Presentation on theme: "Comparative Evaluation of Broad-Panel PCR Assays for the Detection of Gastrointestinal Pathogens in Pediatric Oncology Patients  Zhengming Gu, Haiqing."— Presentation transcript:

1 Comparative Evaluation of Broad-Panel PCR Assays for the Detection of Gastrointestinal Pathogens in Pediatric Oncology Patients  Zhengming Gu, Haiqing Zhu, Alicia Rodriguez, Mohammad Mhaissen, Stacey Schultz-Cherry, Elisabeth Adderson, Randall T. Hayden  The Journal of Molecular Diagnostics  Volume 17, Issue 6, Pages (November 2015) DOI: /j.jmoldx Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 Distribution of positives for BioFire (light gray bars) and Luminex (dark gray bars) by common organism type. Results for detection of common targets by BioFire and Luminex were grouped by organism type; analysis of differences in detection of organism type was accomplished with the McNemar test for paired samples. Differences reached significance for bacteria, P = 0.01; for virus, P = 0.002; and for protozoa, P = 0.004. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 Distribution of positives in BioFire (light gray bars) and Luminex (dark gray bars) by common targets. Results for detection of common targets by BioFire and Luminex were compared and analyzed with the use of the McNemar test for paired samples. ∗P < 0.05, ∗∗P < ETEC, enterotoxigenic E. coli; STEC, Shiga-like toxin-producing E. coli. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

4 Figure 3 Distribution of positives for in-house testing, BioFire, and Luminex. Results for detection of common targets by BioFire, Luminex, and in-house testing were compared and analyzed in pairwise fashion with the use of the McNemar test for paired samples. ∗P < 0.05, ∗∗P < The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions


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