1. Cognitive functioning and depressive symptoms in PCOS: associations with hormone levels and metabolic factors.
Arkadiusz Dudek, Agnieszka Witkowska
Tutors: dr n. med. Krzysztof Krysta, dr n. med. Grzegorz Franik
Students’ Scientific Society, Department of Rehabilitation Psychiatry
Students’ Scientific Society, Department of Endocrinological Gynecology
Medical University of Silesia in Katowice

2. Introduction Polycystic ovary syndrome (PCOS) affects
6.6–8 % of women in reproductive age
PCOS is connected with abnormalities in hormones levels, especially androgens
Insulin resistance

3. What is known already
In patients with PCOS depressive and anxiety symptoms are more common
Differences in cognitive performance was reported in patients with PCOS
verbal fluency verbal memory
manual dexterity visuospatial working memory
Tu jeszcze powiedzieć o związku z testosteronem

4. Aim of the study Analyse if there are assosiations between:
Cognitive deficits
Depressive symptoms
Metabolic risk factors
Hormone levels

5. Methods 55 women (mean age 24.35 ± 4.2) diagnosed with PCOS
Diagnosis based on Rotterdam criteria
All participants underwent a battery of neuropsychological and laboratory tests

6. Neuropsychological tests
TMT A - psychomotor speed, attention and spatial organization
TMT B - attention switching, mental flexibility and recall

7. Verbal Fluency Tests - attention, memory, verbal fluency and executive functions
Beck Depression Inventory
The Stroop Test - selective attention, cognitive flexibility and processing speed

8. Laboratory tests
Hormones: estradiol, FSH, LH, total & free testosterone, 17-OH-progesterone, androstenedione, cortisol, DHEAS, SHBG, PRL, insulin
Metabolic risk factors: glucose, total cholesterol, LDL, HDL, triglycerides, HOMA-IR, QUICKI
Other: BMI, Waist Hip Ratio (WHR)

9. Beck Depression Inventory
Results
Beck Depression Inventory
Fasting glucose
-0,007
OGTT at120’
0,330*
Insulin at 120’
0,21
Triglicerides
0,413**
HDL
- 0,357**
Waist Hip Ratio
0,048
(*) significant at the level of p <0.05, (**) significant at the level of p <0.01

10. Black Stroop Colour Phonological fluency Fasting glucose 0,067 0,315*
0,067
0,315*
OGTT at120’
0,306*
0,047
-0,244
Insulin at 120’
0,283*
0,225
-0,13
Triglicerides
0,058
0,097
-0,081
HDL
0,095
-0,04
-0,066
Waist Hip Ratio
0,252
0,293*
-0,121
(*) significant at the level of p <0.05, (**) significant at the level of p <0.01

11. Beck DI Black Stroop Colour Stroop Phonological fluency SHBG -0,325*
-0,03
-0,051
-0,085
 Androstenedion
0,01
0,139
0,305*
-0,093
 17-OH-progesterone
-0,065
0,034
-0,088
-0,310*
Cortisol at 10 pm
-0,105
0,283*
-0,029
-0,281*
Free testosteron
-0,237
-0,276*
0,086
0,042
(*) significant at the level of p <0.05

12. Conclusions Metabolic factors are connected with depressive symptoms
Different androgens are correlated with different cognitive functions
Insulin resistance parameters are associated with worse verbal psychomotor speed
Study supports the view that

13. Thank you for your attention