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Richard G. Carroll, Seamus J. Martin  Cancer Cell 

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1 Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You 
Richard G. Carroll, Seamus J. Martin  Cancer Cell  Volume 23, Issue 4, Pages (April 2013) DOI: /j.ccr Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Caspase-10 Puts a Brake on Autophagy in Multiple Myeloma
(A) Under steady-state conditions in multiple myeloma, a FLIPL/caspase-10 complex cleaves and inactivates BCLAF1 preventing its participation in autophagy. (B) Upon inhibition or knockdown of caspase-10, BCLAF1 becomes stabilized, displacing Bcl-2 from Beclin-1, leading to excessive autophagy followed by autophagic cell death. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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