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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 139, Issue 6, Pages (December 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Weekly mean change from baseline in CSBM rate (A) and abdominal pain (B) for linaclotide 75, 150, 300, and 600 μg and placebo. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Improvement of postnasal drip symptoms after 8 and 16 weeks of treatment with lansoprazole 30 mg or placebo twice daily. Response is shown as median values and interquartile ranges of improvement on 100 mm VAS scales. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Increased TFF2 promoter methylation correlates with loss of expression in gastric cancer. (A) Quantitative reverse transcription polymerase chain reaction analysis of TFF2 mRNA levels in human gastric mucosal tissues (n = 91); the graph shows the mRNA fold-change relative to normal stomach. Black bars show mean fold-change. *P < .05. (B) TFF2 promoter region scanned by EpiTYPER methylation analysis. Wide black box shows coding regions; narrow black box shows the 5′ untranslated region; arrowheads show transcriptional orientation; TFF2 transcription start site (TSS); base pair (bp) positions are indicated; solid circles show CpGs covered by the analysis; faded circles show nonanalyzed CpGs. (C) EpiTYPER DNA methylation analysis in human gastric mucosal tissues described in (A). Bar graph shows mean CpG methylation ratios (levels). CpG units in pairs 8–9 and 11–12, respectively, are shown as combined averages. *P < .05. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

5 Figure 4 Model for the role of Klf4 in inflammation, the epithelial barrier, and squamous carcinogenesis of the esophagus. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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