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Preventing Primate Gvhd Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Proliferation Predicts Gvhd-Free Survival 

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Presentation on theme: "Preventing Primate Gvhd Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Proliferation Predicts Gvhd-Free Survival "— Presentation transcript:

1 Preventing Primate Gvhd Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Proliferation Predicts Gvhd-Free Survival  Benjamin K. Watkins, MD, Nicolas Poirier, Caroline Mary, Gilles Blancho, Karnail Singh, PhD, Aneesah Garrett, Kelly Hamby, Taylor Deane, Bruce R. Blazar, MD, Bernard Vanhove, PhD, Leslie S. Kean, MD, PhD  Biology of Blood and Marrow Transplantation  Volume 20, Issue 2, (February 2014) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Improved GHVD-free Survival by Blocking CD28
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 CD28-blockade-mediated Inhibition of GVHD Correlates with Control of CD8+ T cell Proliferation. A. % of Proliferating CD8+ T cells Measured Longitudinally Post-transplant. B. Inhibition of CD8+ proliferation correlates with GVHD-free survival. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

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