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Mitchell P. Rosen, M. D. , Shehua Shen, M. D. , Charles E

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1 Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity 
Mitchell P. Rosen, M.D., Shehua Shen, M.D., Charles E. McCulloch, Ph.D., Paolo F. Rinaudo, M.D., Ph.D., Marcelle I. Cedars, M.D., Anthony T. Dobson, M.D., Ph.D.  Fertility and Sterility  Volume 88, Issue 3, Pages (September 2007) DOI: /j.fertnstert Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Linear multivariate analysis for basal ovarian follicular activity (A) and stimulated ovarian follicular activity (B) discriminated by their C677T genotype. All analyses are relative to the wild-type genotype (x-axis, 0 difference). The heterozygous genotype is represented by the solid line, and the mutant genotype is represented by the dashed line. Numbers represent the mean difference of the heterozygous and mutant group from the wild-type, for each of the parameters listed, with confidence intervals. Adjustments (Adj.) are listed at the bottom of each graph. Rosen. MTHFR is associated with ovarian follicular activity. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Linear multivariate analysis for basal ovarian follicular activity (A) and stimulated ovarian follicular activity (B) discriminated by their A1298C genotype. All analyses are relative to the wild-type genotype (x-axis, 0 difference). The heterozygous genotype is represented by the solid line, and the mutant genotype is represented by the dashed line. Numbers represent the mean difference of the heterozygous and mutant group from the wild-type, for each of the parameters listed, with confidence intervals. Adjustments (Adj.) are listed at the bottom of each graph. Rosen. MTHFR is associated with ovarian follicular activity. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions


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