1. Ovarian Cancer Facts and Figures
GEMSTONE Educational Module
Last Update: January 14, 2019
GEMSTONE, a committee of ovarian cancer experts, provided direction and approval of the material in this educational resource. TESARO, Inc. provided writing and organizational support to GEMSTONE in the generation of this material.

2. Module Objectives
Describe public health burden of ovarian cancer in United States
Review shifting trends in ovarian cancer incidence and mortality
Identify how incidence and mortality differ across patient demographics
Compare NIH funding levels for ovarian and breast cancers
NIH, National Institutes of Health.

3. Module Outline Ovarian Cancer Statistics
Risk Factors and Epidemiology by Ethnicity
Current Needs
Summary and Unresolved Questions

4. Ovarian Cancer Statistics

5. Ovarian Cancer Is Relatively Rare Compared With Other Cancers
,530
Incidence in United States1,2
224,940
Prevalence in United States1
new cases per 100,000 women per yeara
2019 projected total new diagnoses
based on 2015 estimates
1.3%
2.5%
Proportion of all new cancer diagnoses in USA in 20181
Proportion of all US cancer diagnoses in women up to 20153
A woman’s lifetime risk of getting ovarian cancer is about 1 in 782
a Age-adjusted data from 2011–2015.
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, American Cancer Society. Key Statistics for Ovarian Cancer. Last revised January 8, Accessed January 9, American Cancer Society. Cancer Facts & Figures cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2018/cancer-facts-and-figures pdf. Published Accessed January 14, 2019.

6. Ovarian Cancer Is the Most Lethal Gynecologic Cancer
,980
Mortality in United States1,2
47.4%
Overall estimated 5-y survival in USA1
deaths per 100,000 women per yeara
2019 projected total deaths
92.3
74.5
29.2 15 20 59
Estimated 5-year survival
Most ovarian cancer diagnoses occur after metastasis, when survival rates decline1
Percentage of diagnosed cases by stage
a Age-adjusted data from 2011–2015.
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, American Cancer Society. Key Statistics for Ovarian Cancer. Last revised January 8, Accessed January 9, 2019.

7. Epidemiological Trends Show a Decline in Ovarian Cancer Incidence and Mortality
Over the last decade, ovarian cancer incidence has declined by 1.5% on average each year, while mortality has declined by 2.3% on average each year
New Cases
Deaths
Number per 100,000 Women
Year
National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, 2019.

8. Mortality of Ovarian Cancer1 vs Breast Cancer1,2
Ovarian Cancer Mortality Has Remained Relatively Stable Compared With Breast Cancer
Mortality of Ovarian Cancer1 vs Breast Cancer1,2
Breast Cancer
Deaths per 100,000 Women
Ovarian Cancer
Year
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, National Cancer Institute. SEER Cancer Stat Facts: Female Breast Cancer. Published April Accessed January 9, 2019.

9. Median Age of Ovarian Cancer Diagnosis Is 63 Years
Age Distribution
Median age at ovarian cancer diagnosis1
63 years
Median age at ovarian cancer diagnosis in women with a BRCA1/2 mutation2
BRCA1
52 years
BRCA2
59 years
BRCA, breast cancer susceptibility gene.
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, Norquist BM, et al. JAMA Oncol. 2016;2(4):

10. Median Age of Death From Ovarian Cancer Is 70 Years
Age Distribution
Median age at death due to ovarian cancer
70 years
National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, 2019.

11. Risk Factors and Epidemiology by Ethnicity

12. Hereditary Cancer Syndromes
Risk and Protective Factors Associated With Likelihood of Developing Epithelial Ovarian Cancer
Risk Factors
Protective Factors
Age
Obesity
Full-Term Pregnancy
OCP Use
Breast- feeding
Fertility Drugs
Hereditary Cancer Syndromes
Tubal Ligation
Hysterectomy
OCP, oral contraceptive pill.
American Cancer Society. Ovarian Cancer Risk Factors. prevention/risk-factors.html. Last revised April 11, Accessed January 9, 2019.

13. Incidence by Ethnicitya,b Mortality by Ethnicitya,c
Ovarian Cancer Incidence and Mortality Rates Are Highest in White Women But Affect All Ethnicities
Incidence by Ethnicitya,b
Mortality by Ethnicitya,c
All Races
White
Black
Asian/ Pacific Islander
American Indian/ Alaska Native
Hispanic
Non-Hispanic
a Age-adjusted data from 2011–2015. b Number of new cases per 100,000 persons. c Number of deaths per 100,000 persons.
National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, 2019.

14. 5-Year Survival in Gynecologic Cancers by Race (2006–2012, all stages)
Black Women With Ovarian Cancer Have a Lower 5-Year Survival Rate Than White Women
5-Year Survival in Gynecologic Cancers by Race (2006–2012, all stages) 69 84 68 82 46 46
5-Year Survival (%) 57 62 36
Siegel RL, et al. CA Cancer J Clin. 2017;67(1):7-30.

15. Current Needs

16. Additional Research Funding Needed to Improve Outcomes for Women With Ovarian Cancer
NIH Funding: Ovarian and Breast Cancers1
Ovarian Cancer
$160 million
Breast Cancer
$755 million
Total NIH Spending, 2018 Estimated (Enacted)
Total funded projectsb 1685
Annual mortality2,a 13,980
Annual mortality3,a 41,760
Total funded projectsb 336
Ovarian Cancer
Breast Cancer
a Estimates for women in b Projects funded in 2017.
NIH, National Institutes of Health.
1. National Institutes of Health. Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC). Research Portfolio Online Reporting Tools (RePORT). Published May 18, Accessed January 9, American Cancer Society. Key Statistics for Ovarian Cancer. Last revised January 8, Accessed January 9, American Cancer Society. How Common Is Breast Cancer? cancer/breast-cancer/about/how-common-is-breast-cancer.html. Last revised January 8, Accessed January 9, 2019.

17. Summary and Unresolved Questions

18. Module Summary
Ovarian cancer is relatively rare compared with other cancer types, but it is the most lethal gynecologic cancer1
Survival is correlated with extent of disease spread at diagnosis1
Estimated 5-year survival in United States:
Localized disease: 92.3%
Distant disease: 29.2%
Ovarian cancer incidence and mortality are declining slightly1
Certain factors may affect risk for ovarian cancer and potential prognosis1,2
1. National Cancer Institute. SEER Cancer Stat Facts: Ovarian Cancer. Published April Accessed January 9, American Cancer Society. Ovarian Cancer Risk Factors. Last revised April 11, Accessed January 9, 2019.

19. Unresolved Questions
How can women modify their diet and lifestyle choices to decrease risk of ovarian cancer?
How does obesity affect risk of ovarian cancer?
How can we improve screening and earlier detection?

20. GEMSTONE
GEMSTONE, a committee of ovarian cancer experts, provided direction and approval of the material in this educational resource. TESARO, Inc. provided writing and organizational support to GEMSTONE in the generation of this material.
TESARO, Inc. | Winter Street | Waltham, MA 02451
©2019 TESARO, Inc. All rights reserved. PP-DS-US /19