1. Effects of 5-Hydroxytryptamine (Serotonin) Type 3 Antagonists on Symptom Relief and Constipation in Nonconstipated Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 
Viola Andresen, Victor M. Montori, Jutta Keller, Colin P. West, Peter Layer, Michael Camilleri 
Clinical Gastroenterology and Hepatology 
Volume 6, Issue 5, Pages (May 2008)
DOI: /j.cgh
Copyright © 2008 AGA Institute Terms and Conditions

2. Figure 1 Trial selection flow. *One study reported only safety data.
Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh )
Copyright © 2008 AGA Institute Terms and Conditions

3. Figure 2
Patients responding to alosetron or cilansetron regarding relief of abdominal pain and discomfort.
Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh )
Copyright © 2008 AGA Institute Terms and Conditions

4. Figure 3
Patients responding to alosetron or cilansetron regarding global improvement of IBS symptoms.
Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh )
Copyright © 2008 AGA Institute Terms and Conditions

5. Figure 4
Number of patients developing constipation. *Subgroup treatment interaction with an RR ratio of 0.65 (0.41–0.99).
Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh )
Copyright © 2008 AGA Institute Terms and Conditions

6. Figure 5
Funnel plots. (A) End point: relief of abdominal pain and discomfort. (B) End point: global improvement of IBS symptoms.
Clinical Gastroenterology and Hepatology 2008 6, DOI: ( /j.cgh )
Copyright © 2008 AGA Institute Terms and Conditions