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Disposition index identifies defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance  L. Merjaneh, Q. He, Q. Long, L.S.

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Presentation on theme: "Disposition index identifies defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance  L. Merjaneh, Q. He, Q. Long, L.S."— Presentation transcript:

1 Disposition index identifies defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance  L. Merjaneh, Q. He, Q. Long, L.S. Phillips, A.A. Stecenko  Journal of Cystic Fibrosis  Volume 14, Issue 1, Pages (January 2015) DOI: /j.jcf Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 The computed slopes for ln(Insulin secretion) versus ln(Insulin sensitivity) in the five groups showing that the slope includes −1 for all groups except CFRD. The slope and confidence interval (CI) for each of the groups is as follows. Con-NGT: slope − with CI [−1.6383, ]; Con-prediabetes: slope − with CI [−1.4689, −0.4707]; CF-NGT: slope − with CI [−1.0339, ]; CF-prediabetes: slope − with CI [−1.2518, ]; CFRD: slope − with CI [− , −7.4637]. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 The disposition index in controls and CF subjects according to their glucose tolerance category. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 ROC curves for DI and 30-min glucose levels on determination of normal glucose tolerance (a) and determination of diabetes (b). TPR: true-positive rate; FPR: false-positive rate. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions


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