1. Counterterrorism: A Cure for Anthrax
A Proposed Method for Combating Anthrax Infection in Humans

2. Anthrax: An Introduction
Caused by Bacillus anthracis
Three forms:
Cutaneous
Not usually fatal
Enteric
25-60% mortality rate
Inhalational
100% mortality rate if left untreated
Signs and Symptoms:
URI
Dyspnea, diaphoresis, myalgia
Septic shock

3. Anthrax: The Assassin’s Choice
High mortality
Non-transmissable
Stores for years
Dispersion

4. Pathogenesis of Anthrax

5. The Key
Anthrax relies on Protective Antigen (PA) to function (allows endocytosis of LF and EF)

6. Proposed BioBrick UPI0000027636 Remodel MIDAS region
Mus musculus version of Anthrax Toxin Receptor
Remodel MIDAS region
UPI : MDRAGRLGAGLRGLCVAALVLVCAGHGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEI YYFVEQLAHRFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHE GFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKD FNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVR GNGFRHARNVDRVLCSFKINDSVTLNEKPFAVEDTYLLCPAPILKEVGMKAALQVSMNDG LSFISSSVIITTTHCSDGSILAIALLVLFLLLALALLWWFWPLCCTVIIKEVPPPPVEES EEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPE QEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCI NFTRVKNSQPAKYPLNNTYHPSSPPPAPIYTPPPPAPHCPPPAPSAPTPPIPSPPSTLPP PPQAPPPNRAPPPSRPPPRPSV