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European Urology Oncology
Defining the Most Informative Intermediate Clinical Endpoints for Predicting Overall Survival in Patients Treated with Radical Prostatectomy for High-risk Prostate Cancer Alberto Martini, Giorgio Gandaglia, R. Jeffrey Karnes, Emanuele Zaffuto, Marco Bianchi, Paolo Gontero, Piotr Chlosta, Christian Gratzke, Markus Graefen, Derya Tilki, Vito Cucchiara, Vincenzo Mirone, Burkhard Kneitz, Rafael Sanchez Salas, Henk Van Der Poel, Bertrand Tombal, Martin Spahn, Thomas Steven Joniau, Francesco Montorsi, Alberto Briganti European Urology Oncology DOI: /j.euo Copyright © Terms and Conditions
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Fig. 1 Probability of overall survival (OS) estimated with the Kaplan-Meier method and probability of cancer-specific survival (CSS) and other-cause mortality (OCM) estimated with the competing risks method. RP=radical prostatectomy. European Urology Oncology DOI: ( /j.euo ) Copyright © Terms and Conditions
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Fig. 2 Kaplan-Meier estimates of freedom from biochemical recurrence and clinical recurrence. BCR=biochemical recurrence; CR=clinical recurrence; RP=radical prostatectomy. European Urology Oncology DOI: ( /j.euo ) Copyright © Terms and Conditions
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Fig. 3 Kaplan-Meier estimates illustrating landmark analyses for overall survival, according to the development of biochemical recurrence (BCR) and clinical recurrence (CR) within 1, 3, 5, and 7yr from radical prostatectomy (RP). RP=radical prostatectomy. European Urology Oncology DOI: ( /j.euo ) Copyright © Terms and Conditions
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Fig. 4 Kaplan-Meier estimates illustrating landmark analyses for overall survival, according to the progression to clinical recurrence (CR) within 1, 3, 5, and 7yr from the development of biochemical recurrence (BCR). European Urology Oncology DOI: ( /j.euo ) Copyright © Terms and Conditions
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Fig. 5 Kaplan-Meier estimates for overall survival, considering patients who developed biochemical recurrence (BCR) within 5yr of surgery and progressed to clinical recurrence (CR) within 12mo of BCR. RP=radical prostatectomy. European Urology Oncology DOI: ( /j.euo ) Copyright © Terms and Conditions
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