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Lung Cancer: A Wily Genetic Opponent

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1 Lung Cancer: A Wily Genetic Opponent
Peggy P. Hsu, Alice T. Shaw  Cell  Volume 169, Issue 5, Pages (May 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Strategies for Countering ITH and Evolution in the Clinic
At time of diagnosis (A), ITH exists, allowing for tumor evolution both in the absence (B) and presence (D) of treatment. Early detection, targeting truncal mutations (C), or inhibiting underlying mechanisms by which heterogeneity is generated (E) are approaches to address ITH. Rationally sequencing therapies might allow us to predict and actively shape tumor evolution (F). Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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